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KMID : 1059519910350050575
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Journal of the Korean Chemical Society
1991 Volume.35 No. 5 p.575 ~ p.579
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Synthesis of 6-(Carboxymethylthio) penicillanic Acid Derivatives from 6β-Bromopenicillanates
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Choi Won-Sik
Lee Young-Haeng
Lee Chai-Ho
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Abstract
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Reaction of 6β-bromopenicillanic acid(4a) with p-nitrobenzylbromide, 3-bromophthalide, chloromethylpivalate and 1-chlorodiethylcarbonate afforded 6β-bromopenicillanates(4b~4e). New β-lactam compound, 6-(carboxymethylthio)penicillanic acid(5a) and the other esters(5b~5e) were prepared by nucleophilic substitution reaction of 6β-bromopenicillanic acid(4a) and the other esters(4b~4e) with thioglycolic acid.
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